The 
previous the year saw the Diamondbacks improve to a respectable 79-83 record. The team would be managed by Chip Hale who is in his second year as D-backs manager.
On April 4, 2016 the Diamondbacks hosted the Colorado Rockies at Chase Field in Phoenix AZ.
Right-handed pitcher Zack Greinke would make his first Opening Day start with the Arizona Diamondbacks.
The Opening Day line-up featured six changes from the previous season and one position change.
Chris Owings would get his third Opening Day start this year at center field taking over for the injured A.J. Pollock. Jean Segura made his first Opening Day start for the Diamondbacks playing second base. Nick Ahmed got his second career Opening Day start at shortstop while Paul Goldschmidt played first base for the fifth consecutive year. Greinke was the Opening Day starting pitcher for the second time in his career.
Besides Segura, the new Opening Day starters were Wellington Castillo who started at catcher, David Peralta who started at right field, Yosmany Tomas in left field, and Jake Lamb who was the starting third baseman in his young career.
For the ninth time in franchise history the Diamondbacks lost their season opener. The final score Diamondbacks 5 - Giants 10 in front of 48,165.
| 2016 | ||
| Order | Name | Position |
| 1. | Jean Segura | 2B |
| 2. | Chris Owings | CF |
| 3. | Paul Goldschmidt | 1B |
| 4. | Wellington Castillo | C |
| 5. | David Peralta | RF |
| 6. | Yosmany Tomas | LF |
| 7. | Jake Lamb | 3B |
| 8. | Zack Greinke | P |
| 9. | Nick Ahmed | SS |
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