The 
previous the year saw the Diamondbacks struggle to a disappointing 69-93 record. The team would be managed by Torey Lovullo who is in his first year as D-backs manager.
On April 2, 2017 the Diamondbacks hosted the San Francisco Giants at Chase Field in Phoenix AZ.
Right-handed pitcher Zack Greinke would make his second Opening Day start with the Arizona Diamondbacks.
The Opening Day line-up featured two changes from the previous season and one position change.
Chris Owings would get his fourth Opening Day start this year at shortstop after playing center field last season. Brandon Drury made his first Opening Day start for the Diamondbacks playing second base. Paul Goldschmidt played first base for the sixth consecutive year. Greinke was the Opening Day starting pitcher for the second time for the Diamondbacks.
Besides Drury, the new Opening Day starter was Jeff Mathis who started at catcher. David Peralta started at right field for the second straight year, Yasmany Tomas in left field, and Jake Lamb was the starting third baseman for the second time.
For the tenth time in franchise history the Diamondbacks won their season opener. The final score Diamondbacks 7 - Giants 6 in front of 49,016.
| 2017 | ||
| Order | Name | Position |
| 1. | A.J. Pollock | CF |
| 2. | Chris Owings | SS |
| 3. | Paul Goldschmidt | 1B |
| 4. | Jake Lamb | 3B |
| 5. | Yasmany Tomas | LF |
| 6. | Brandon Drury | 2B |
| 7. | David Peralta | RF |
| 8. | Jeff Mathis | C |
| 9. | Zack Greinke | P |
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