After missing 
the post season the previous year the Diamondbacks made wholesale changes to their roster as they attempted another run to the playoffs.
On April 6, 2004 the Diamondbacks would host the Colorado Rockies at Bank One Ballpark in Phoenix AZ.
For the fifth straight year left-handed pitcher Randy Johnson would take the mound for the Arizona Diamondbacks.
The Opening Day line-up featured five different players from the previous season.
Newly acquired Roberto Alomar would play second base. Slugger Richie Sexon whom the Diamondbacks traded for that off-season played first base. Alex Cintron took over at shortstop. Shea Hillenbrand was the Diamondbacks new third baseman. The catching duties were turned over to Brent Mayne.
For the fourth time in franchise history the Diamondbacks lost their season opener. The final score Diamondbacks 2 - Rockies 6 in front of 46,949.
| 2004 | ||
| Order | Name | Position |
| 1. | Steve Finley | CF |
| 2. | Roberto Alomar | 2B |
| 3. | Luis Gonzalez | LF |
| 4. | Richie Sexon | 1B |
| 5. | Alex Cintron | SS |
| 6. | Shea Hillenbrand | 3B |
| 7. | Danny Bautista | RF |
| 8. | Brent Mayne | c |
| 9. | Randy Johnson | LHP |
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